Cholinergic mechanisms of high-frequency stimulation in entopeduncular nucleus
نویسندگان
چکیده
منابع مشابه
High-Frequency Stimulation of the Rat Entopeduncular Nucleus Does Not Provide Functional or Morphological Neuroprotection from 6-Hydroxydopamine
Deep brain stimulation (DBS) is the most common neurosurgical treatment for Parkinson's disease (PD). Whereas the globus pallidus interna (GPi) has been less commonly targeted than the subthalamic nucleus (STN), a recent clinical trial suggests that GPi DBS may provide better outcomes for patients with psychiatric comorbidities. Several laboratories have demonstrated that DBS of the STN provide...
متن کامل[High frequency stimulation of the subthalamic nucleus in Parkinson's disease].
has been a part of the CNRS unit of Professor Bernard Bioulac in Bordeaux since 2001, prior to which he was 'Chargé de Recherche' (CR1). For his PhD, which he obtained in 1993 in the field of neuroscience and pharmacology, Dr Benazzouz investigated a new therapeutical approach with high-frequency stimulation (HFS) of the subthalamic nucleus in a non-human primate model of Parkinson's disease (P...
متن کاملEnhancement of Frequency Domain Indices of Heart Rate Variability by Cholinergic Stimulation with Pyridostigmine Bromide
Pyridostigmine bromide (PB) is a reversible cholinesterase inhibitor. The aim of this study was to determine the effect of orally administration of single dose sustained-released tablet of pyridostigmine bromide (PBSR) on the frequency domain indices of heart rate variability (HRV). Thirty-two healthy young men were participated in this study. They were divided into 2 groups; the pyridostigmine...
متن کاملNucleus accumbens high-frequency stimulation selectively impacts nigrostriatal dopaminergic neurons.
High-frequency stimulation of the nucleus accumbens, also known as deep brain stimulation (DBS), is currently used to alleviate obsessive compulsive symptoms when pharmacotherapy is ineffective. However, the mechanism by which DBS achieves its therapeutic actions is not understood. Imaging studies and the actions of dopaminergic drugs in untreated patients suggest that the dopamine (DA) system ...
متن کاملHigh but not low frequency stimulation of both the globus pallidus and the entopeduncular nucleus reduces 'compulsive' lever-pressing in rats.
The anti-compulsive effects of high and low frequency stimulation (LFS, HFS) of the entopeduncular nucleus and globus pallidus (the rat's equivalent, respectively, of the primate's internal and external segments of the globus pallidus) were assessed in the signal attenuation rat model of obsessive-compulsive disorder (OCD). HFS, but not LFS, of the two nuclei exerted an anti-compulsive effect, ...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2016
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00269.2015